A key feature of cancer cells is their forced proliferation, which causes a hasty uncontrolled start of DNA replication. To date, however, little is known about the mechanisms that control the start ...

These essential enzymes maintain genome integrity and play a vital role in DNA replication and repair across all living organisms. By forming phosphodiester bonds, it ensures the seamless connection ...

Inside every human cell, 2 meters of DNA must be tightly packed ... like gene expression and DNA replication." The researchers plan to use Repli-Histo labeling to create a chromatin behavior ...

A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication. Cell lines ...

Movie 1: Movement of single nucleosomes in living human cells. The movie shows nucleosome fluctuations in euchromatin (left), where gene expression is active, and in heterochromatin (right), where ...

In their new study, the researchers studied the DNA replication patterns in early embryos. "We discovered differences in the replication mechanisms of maternal and paternal DNA during the initial ...

Because DNA replication errors or environmental agents that damage DNA can introduce mutations if not corrected, multiple cellular DNA repair mechanisms exist to remove damaged regions of ...

The review summarizes (i) key findings on replication and copy number control processes that involve DNA-binding proteins and (ii) current knowledge on key factors of the pIP501 T4SS whose activity ...