A targeted drug therapy has shown potential to reverse cellular damage in Parkinson’s disease by regenerating critical brain structures and restoring neuron function, according to new findings from a ...

Here, we show that hESC-derived dopaminergic neurons survived a long-term transplantation to the neurotoxin 6-hydroxydopamine (6-OHDA) lesioned rat striatum, and in combination with those cells ...

Dopamine has long been known for its critical role in cue-reward associations, and new data provide a much richer and complex image of how dopaminergic neurons function. Making decisions about ...

Currently dopamine replacement medications, like levodopa and dopamine agonists, are the primary treatment for Parkinson's ...

Fly protein has protective effect on dopaminergic neurons Date: October 3, 2018 Source: Lehigh University Summary: A team recently identified the fruit fly protein known as Scarlet as a target ...

Knock out expression of Nrg3 in the dopaminergic neurons increased dopaminergic terminals in the prefrontal cortex and Nucleus accumbens, also increased dopamine transients in the core of nucleus ...

More information: Taylor Russo et al, Lipid accumulation drives cellular senescence in dopaminergic neurons, Aging (2024). DOI: 10.18632/aging.206030. Provided by Impact Journals, LLC.

Reactive astrocytes in SNpc produce excessive GABA via MAO-B in animal models of PD. Aberrant tonic inhibition of dopaminergic neurons causes reduced dopamine production in neurons and motor deficits.

Autologous mesenchymal stem cell–derived dopaminergic neurons function in parkinsonian macaques. Journal of Clinical Investigation , 2012; DOI: 10.1172/JCI62516 Cite This Page : ...

The awakening of dormant dopaminergic neurons leads to a significant alleviation of PD motor symptoms. They also used optogenetic tools to inhibit dopaminergic neuron of normal rats, inducing ...