The lower dose of 2.5 mg twice daily also resulted in fewer ... API-CAT was designed to test whether a lower dose of apixaban could continue to be protective while blunting the bleeding risk posed by ...

or 10 mg (5 mg twice daily; the full-dose group) of apixaban for an additional 12 months. Neither patients nor their doctors knew which dose patients were receiving until the end of the trial.

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For CrCl ≤15 mL/min, CKD stage V, no data available for any of the agents listed. ARISTOTLE indicates Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation; bw, body ...