A new drug application for apixaban for stroke prophylaxis in patients with nonvalvular AF was submitted to FDA in 2011. ... Apixaban 5 mg twice daily plus standard care. ... 20/8759 (0.2 ...

If these drugs must be coadministered, a rivaroxaban dose increase to 20 mg (i.e., two 10-mg tablets) should be considered. ... Apixaban 5 mg twice daily plus standard care.