Efficacy of conventional synthetic disease-modifying antirheumatic drugs, glucocorticoids and tofacitinib: a systematic literature review informing the 2013 update of the EULAR recommendations for ...

Most tissues express glucocorticoid receptors but tissue-specific modulation of this receptor affects homeostasis, immune responses and cell differentiation mediated by glucocorticoids. This ...

The US biosimilar market expands with new denosumab options, enhancing treatment for patients with osteoporosis and ...

Stoboclo and Osenvelt, FDA-approved biosimilars of Prolia and Xgeva, are now available in the U.S. for variois cancers and ...

STOBOCLO ® (denosumab-bmwo) and OSENVELT ® (denosumab-bmwo) are approved by FDA for all indications of PROLIA ® (denosumab) and XGEVA ® (denosumab) respectively [1], [2] STOBOCLO and OSENVELT, among ...

Diflavin-linked disulfide oxidoreductases (DDORs) are structurally related to the low - molecular-weight type NADP-dependent thioredoxin reductases, although they do not share a common function. The ...

Guidelines recommend minimizing glucocorticoid exposure in patients with lupus (SLE), and research suggests this advice should also apply to those with lupus nephritis.

Equivalent uniform dose (EUD) is a biomedical indicator based on the dose measure. In this paper, the dose volume histogram is used to describe the dose distribution of different tissues in target and ...

Glucocorticoids induce specific ion-channel-mediated toxicity in human rotator cuff tendon: a mechanism underpinning the ultimately deleterious effect of steroid injection in tendinopathy?

A division of the Unified Patent Court (UPC) has recommended that the UPC set its own legal test for determining how rights holders can claim their patents have been infringed by reference to how ...

Estrogens stimulate whereas androgens inhibit brown adipose tissue (BAT) activity directly and indirectly via the brain. Glucocorticoids directly inhibit BAT activity and androgens potentiate this ...