This study identifies E75/NR1D2 as an evolutionarily conserved oncogene that promotes malignant transformation of benign tumors by co-regulating the Hippo and Notch signaling pathways. The ecdysone ...

Types of cell signalling pathways include checkpoint ... morphogen signalling, Hippo signalling, TOR signalling and integrin signalling. BMP signaling is important for multiple process, including ...

The company is advancing five clinical, preclinical and discovery programs: IK-007, an EP4 receptor antagonist; IK-175, an AHR antagonist; IK-412, a kynurenine-degrading enzyme Kynase; discovery-stage ...

THRAP3, STMN1, and GNA13—are overrepresented in blood cancers like acute myeloid leukemia (AML) and could prove to be novel ...

(G) Schematic model of NIC-associated signaling pathway in ISCs. The model traces a signaling cascade via α7-nAchR, PKC, Hippo-YAP/TAZ and Notch signaling in ISCs. Values represent the mean ± SEM.

The authors further provided data supporting that the effects of nicotine on stem cell proliferation and tumor initiation were mediated by the Hippo-YAP/TAZ and Notch signal pathway. Strengths and ...

Here, Begovich and colleagues present a SOS1 bifunctional degrader, BTX-6654, that demonstrates potent SOS1 degradation and inhibits downstream signaling and proliferation ... SWTX-143, Blocks Hippo ...

Inventiva’s lead product candidate, lanifibranor, is currently in a pivotal Phase III clinical trial, NATiV3, for the treatment of adult patients with MASH, a common and progressive chronic liver ...

Trafficking in irreverence, the film follows a pair of stepsiblings with sexual tension. By Natalia Winkelman When you purchase a ticket for an independently reviewed film through our site, we ...