Alkanediols such as 1,6-hexanediol disrupt many phase-separated condensates in cellula and in vitro, but how molecular interactions are perturbed by these compounds remains unclear. This study uses ...

MANY of the ill effects of a lack of sufficient or suitable proteins in the diet are encountered at all ages and in both pregnant and nonpregnant women. Some of them are particularly likely to ...

TyG, triglyceride-glucose index; hsCRP, high-sensitivity C-reactive protein. Table 2 displays the combined effect of TyG index and hsCRP levels on the hazard of cardiometabolic multimorbidity, using ...

"Now that we know the properties of protein cores under typical folding conditions, it's possible that protein core packing does not need to stop at 55%," said Alex Grigas, a Ph.D. candidate in O ...

College of Food Science and Engineering, Shandong Agricultural University, Tai’an, Shandong 271018, China Engineering and Technology Center for Grain Processing in Shandong Province, Tai’an, Shandong ...

Protein aggregates are spatially organized and regulated in cells to prevent deleterious effects of proteostatic stress. Misfolding of proteins in the ER result in aggregate formation, but how the ...

Scientists have long struggled to target proteins that lack defined structure ... leading to the temporary paralysis effect seen after Botox treatments. To reprogram this precision for α ...

In its initial application, we employed the TIP3P water model, optimized for CHARMM36m proteins, to simulate the water behavior ... All models successfully distinguished hydrophobic from hydrophilic ...

and found that hydrogen bonding and hydrophobic interactions were the main driving forces. Because of the synergistic effect of glycyrrhizin and salbutamol in improving asthma, we revealed the ...

Mutations in the intracellular domain can have profound effects on receptor activities. Many cells in our body release signals that trigger responses in other cells. A protein called PEDF is a signal ...