Two weeks after faltering on the road to the Los Angeles Rams, the 49ers blew another 10-point lead and exited with a 24-23 ...

The San Francisco 49ers were thought to be among the favorites to represent the NFC in the Super Bowl for a second straight year, but they haven't ...

After swapping his cleats for a microphone, the spotlight during Sunday's game between the San Francisco 49ers and Arizona ...

San Francisco 49ers running back Jordan Mason's best plays vs. the New York Jets in the Week 1 matchup. Watch the New York Jets vs. the San Francisco 49ers highlights from the Week 1 matchup.

Head coach Kyle Shanahan told reporters Friday that the team put in a request to the NFL to switch from their usual red home ...

During the San Francisco 49ers’ season opener ... on Pearsall at San Francisco General Hospital. The three took photos with Pearsall in between offensive series during Monday’s game and ...

Brock Purdy and the San Francisco 49ers took on Aaron Rodgers and the New York Jets on Monday Night Football in their season opener at Levi’s Stadium as they seek to return to the Super Bowl.

San Francisco 49ers inquired about Justin Jefferson in the offseason, amid Brandon Aiyuk contract holdout. More Adam Bettcher/Getty Images Against the 49ers, Jefferson recorded 133 receiving yards ...

The NFL certainly didn't disappoint in Week 5, one of the wildest weeks in the young year. Five games featured the ...

San Francisco 49ers left tackle Trent Williams said he ... More Lachlan Cunningham/Getty Images In spite of an ongoing contract saga, the left tackle experience a moment of shock as he was able ...

Brock Purdy and the San Francisco 49ers took on Aaron Rodgers and the New York Jets on Monday Night Football in their season opener at Levi’s Stadium as they seek to return to the Super Bowl.