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Those on irbesartan were started on 150 mg and increased to 300 mg at week 2. Treatment was started after a 2-week washout period without renin-angiotensin system (RAS) inhibition.

The annual eGFR chronic slope (week 6 to 108) declined less in the sparsentan arm than irbesartan arm (-4.8 vs -5.7 mL/min/1.73 m 2) but the 0.9 mL/min/1.73 m 2 difference was not significant.

Mean change in eGFR from baseline to week 112 was -10.4 mL/min/1.73 m 2 with sparsentan and -12.1 mL/min/1.73 m 2 with irbesartan, also not a significant difference, reported Howard Trachtman, MD ...

Aprovel (300 mg) 300mg - 14 Tablets (Irbesartan) drug information. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes . It is manufactured by Sanofi ...

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Both secukinumab 300 mg (28.2%) and 150 mg (24.3%) also led to higher ACR50 response rates at week 16 compared with placebo (5.8%), both with significant ORs.

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