Researchers from Osaka Metropolitan University have identified a gene that, when activated by metabolic stress, damages ...

A new study from the Cellular Aging and Senescence laboratory at Queen Mary University of London's Centre for Molecular Cell ...

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations ...

A new study from Imperial has shown that the physical structure of food influences the hormones released as part of digestion ...

Hyperglycemia-induced mitochondrial dysfunction contributes to sensory neuron pathology in diabetic neuropathy. Although Schwann cells (SCs) also undergo substantial degeneration in diabetic ...

Furthermore, mitochondria play a central role in regulating apoptosis through the release of cytochrome c, which activates caspase-dependent cell death pathways. (8) By inducing mitochondrial ...

At the second point during the young‐cell period, a separate cell culture was derived from the above culture, which was treated by introduction of the p53 dominant‐negative peptide, GSE56. The cluster ...

Mitochondrial Ca 2+ signaling controls cell metabolism and cell death by necrosis, apoptosis, and autophagy. 61 For example, transient fluctuations in mitochondrial Ca 2+ activate 3 matrix ...

These mitochondrial abnormalities are seen in ALS cell models associated with various genetic mutations, implying that this could be a treatment target for many genetic forms of ALS. “This means that ...

MCT1-mediated histone lactylation modulates lung cancer cell sensitivity to T-cell–mediated killing by influencing mitochondrial dysfunction.. JCO 43 , e20051-e20051 (2025). DOI: ...

Our findings suggest that cellular dysfunction observed in GD, like that of PD, is a consequence of defects in autophagy/mitophagy pathways, resulting in failed clearance of damaged mitochondria. In ...