Explore the advantages of virtual screening in drug discovery, offering rapid evaluation and cost savings over traditional ...
Protein serine/threonine kinases (STKs) regulate critical signaling pathways involved in cell growth, proliferation, metabolism, and apoptosis. Aberrant kinase activity is implicated in diverse human ...
Researchers led by Dr. W. David Hill at the University of Edinburgh have identified a significant genetic correlation between childhood cognitive function and longevity, providing the first molecular ...
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Intrinsically disordered proteins (IDPs) are implicated in many human diseases and are increasingly being pursued as drug targets. Conventional structure-based drug design methods that rely on ...
Investigating the oncolytic bacteria product SGN1 and its impact on PD-L1 expression, CD8+ T cell infiltration, and synergy with anti-PD-L1 combo in preclinical models of pancreatic adenocarcinoma, ...
Abstract: Structure-based virtual screening (VS) often produces creative lead compounds while considering the target’s 3-D structure by applying in-depth molecular docking research results. The ...
Introduction: To design effective small molecule inhibitors targeting the immune checkpoint PD-1/PD-L1 and to explore their inhibitory activity. Methods: In this paper, a total of 69 PD-1/PD-L1 ...
Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. We describe our winning submission to the first Critical Assessment of Computational ...
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