These processes involve synaptic transmission, in which chemical signals are transmitted ... are released at a synapse (a ...

The capsid of the virus-derived retrotransposon Copia, a parasitic genome element, mediates synaptic plasticity at the Drosophila neuromuscular junction  ...

Motor movement is controlled by the brain through transmitting electrochemical signals to the muscle fibers that cause the contraction of the muscles. A motoneuron carrying the impulse creates a ...

We show that the Huntington's disease (HD)-associated mutant HTT exon 1 protein (mHTTEx1) is transmitted from neurons to muscle cells across the human neuromuscular junction. We found that ...

A human self-organizing 2D neuromuscular junction model. Immunofluorescence analysis of the whole dish shows muscle cells (magenta) organized in bundles surrounded by spinal cord neurons (cyan).

More information: Ruslan Stanika et al, An ex vivo Model of Paired Cultured Hippocampal Neurons for Bi-directionally Studying Synaptic Transmission and Plasticity, Bio-protocol (2023).

Original publications: An ex vivo Model of Paired Cultured Hippocampal Neurons for Bi- directionally Studying Synaptic Transmission and Plasticity. Stanika, R. & Obermair, G. J. (2023). Bio-protocol ...

The first functional stem-cell derived neuromuscular junction model has recently been licensed, which could help the quest to develop new drugs to treat associated neurodegenerative diseases. We ...

James F. Howard Jr, MD, professor of neurology at the University of North Carolina at Chapel Hill, explains how nerve and muscle signaling in the neuromuscular junction go awry in myasthenia gravis.

The team identified SYT3 as a presynaptic high-affinity Ca 2+ sensor, which, they say “drives vesicle replenishment and short-term synaptic plasticity.” They generated SYT3 knockout mice.

Unique human neuromuscular junction assay establishes skeletal muscle as a key player in ALS October 18, 2022 01:27 PM Eastern Daylight Time ...