For more than a century, the well-known 18-electron rule has guided the field of organometallic chemistry. Now, researchers ...

Chemists at UCLA have discovered a flaw in one of organic chemistry’s longstanding principles, challenging a rule that's guided synthetic chemistry for a century. Known as Bredt’s rule, the ...

One of the first reactions that students learn in college-level organic chemistry is hydrochlorination—adding hydrogen ... according to a selectivity principle known as the Markovnikov rule.

Previous work on nucleophilic additions catalysed by chiral Brønsted acids has been restricted to polarized heteroatom-containing functionalities such as imines, aziridines and carbonyls. This ...