This is a valuable and rigorous study that addresses the question of what determines the spatial organization of endocytic zones at synapses. The authors use compelling approaches, in both Drosophila ...

A version of this article appears in print on , Section B, Page 11 of the New York edition with the headline: Ed Smylie Dies at 95; His Team of Engineers Saved Apollo 13 Crew.

Insilico Medicine Ltd. has identified postsynaptic density-95 (PSD-95) protein inhibitors acting as neuroprotective agents reported to be useful for the treatment of epilepsy, anxiety disorders, ...

The loss of colocalization with synaptophysin reflected not only the large reduction in immunoreactive clusters of PSD-95, chapsyn-110 and GKAP, but also the poor overlap of the remaining diffuse ...

Additionally, these results are in agreement with the recent observation that NFL in the CSF, in contrast to neurogranin, is more increased in CJD VV2 cases than in MM1, 34 with VV2 cases showing ...

In a new study that could pave the way for new treatments targeting age-related cognitive decline, researchers have discovered that low-dose, long-term administration of a key cannabis component can ...

To this end, we used a mouse model deficient for DNA-PKcs to show that its kinase activity has a role in synaptic plasticity. We find that in DNA-PKcs −/− mice LTP is impaired by lack of PSD-95 ...

University of Copenhagen has described cyclic peptides acting as postsynaptic density-95 (PSD-95) protein inhibitors reported to be useful for the treatment of neuropathic pain.

Studies on the following synaptic markers were included: structural dendritic changes (e.g., dendritic spine density, arborization), PSD-95, synapsin-1, synaptophysin-1, synaptotagmin-1, and SV2A.

The complex between the N-methyl-d-aspartate receptor (NMDAR), neuronal nitric oxide synthase (nNOS), and the postsynaptic density protein-95 (PSD-95) is an attractive therapeutic target for the ...

The scaffold protein PSD-95 links postsynaptic receptors to sites of presynaptic neurotransmitter release. Flexible linkers between folded domains in PSD-95 enable a dynamic supertertiary structure.