Dizal will also present results from the ongoing Phase I/II study of DZD6008, a 4th generation EGFR TKI with full BBB penetration, in advanced EGFR mutation positive (EGFRm) non-small cell lung cancer ...

HUTCHMED (China) Limited (“ HUTCHMED ”) (Nasdaq/AIM:​HCM; HKEX:​13) today announces that new and updated data from several studies of compounds discovered by HUTCHMED including savolitinib, ...

This study presents a valuable finding on the direct cytotoxic effects of DuoHexaBody-CD37 in diffuse large B-cell lymphoma, mediated via SHP-1 activation and antibody clustering, independent of ...

An estimated 18,000 people in the United States annually suffer from new injuries to their spinal cords. Unfortunately for ...

Here we studied the role of Fms-like tyrosine kinase 3 ligand (Flt3L) signalling in the pathogenesis of collagen-induced arthritis (CIA). Methods CIA was induced in mice lacking Flt3L (Flt3L −/−) and ...

We aimed to define the impact of VD on oesophageal allergic inflammation. Design We assessed the genomic distribution and function of VD receptor (VDR) and STAT6 using histology, molecular imaging, ...

The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal transduction system linking the activation of receptor tyrosine kinases ... frequently activated signalling pathways in human ...

The phosphoinositide signalling system can be viewed as a network of interconverting enzymes, phospholipid messengers and their binding proteins. Interactions between phosphoinositides and their ...

“Pirtobrutinib has added an entire line of therapy for patients with progression on covalent BTK [Bruton’s tyrosine kinase ... “block B-cell receptor signaling to impair survival and ...

A subcategory of TKIs emerges: Bruton’s tyrosine kinase (BTK) inhibitors. They regulate immune cell signaling instead of growth factor receptors and have gained traction in B-cell malignancies as BTK ...

Sulfated HSPGs play a vital regulator of heparin binding growth factor signaling, e.g., FGF2, VEGF, HGF, PDGF, and heparin binding EGF (HB-EGF), also known as receptor tyrosine kinase (RTK) signaling ...

EGFR is one of four members of the ErbB family of receptor tyrosine kinases that have key ... Several of these signaling pathways, such as phosphatidylinositol 3-kinase, are known mediators of pain.