Ribosomes are the cell's protein factories, which read the genetic code and assemble the proteins that every organism needs to live. But as far as how ribosomes themselves were formed, tantalizingly ...
Cells endure starvation conditions by rewiring their metabolic pathways. For example, in yeast, ribosomes are known to coat mitochondria. Exactly how this behavior promotes survival has remained ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Chloroplast-encoded multi-span thylakoid ...
Building on previous work from the Tansey lab, here Howard et al. characterize transcriptional and translational changes upon WIN site inhibition of WDR5 in MLL-rearranged cancer cells. They first ...
The chromatin-associated protein WD Repeat Domain 5 (WDR5) is a promising target for cancer drug discovery, with most efforts blocking an arginine-binding cavity on the protein called the ‘WIN’ site ...
Researchers at LMU and Stanford University reveal how cells regenerate protein factories at endoplasmic reticulum. The synthesis of proteins in the cell is a key process of life. By this means, the ...
New high-resolution images have provided insights into how the large subunit of human ribosomes assembles, advancing our understanding of these essential cellular machines. The findings, which ...