The Cardinals beat the 49ers, 24-23, on Sunday afternoon in Santa Clara, a win that changed the outlook of their season.

According to the latest odds available at DraftKings Sportsbook, the Seahawks are three-point underdogs at home for this week ...

Tom Brady reminisced on facing San Francisco 49ers quarterback Brock Purdy in 2022, the final season of his career.

The 49ers just blew another 10-point fourth quarter lead and lost 24-23 to the Arizona Cardinals. Now the 49ers are 2-3. Here ...

San Francisco veteran kicker Jake Moody suffered a high right ankle sprain while attempting to make a tackle on a kick return ...

The 49ers are a 7.5-point favorite over the Cardinals in NFL Week 5 odds for the game, courtesy of BetMGM Sportsbook. San ...

Two weeks after faltering on the road to the Los Angeles Rams, the 49ers blew another 10-point lead and exited with a 24-23 ...

The defense wilted in the heat, the offense couldn’t finish drives or protect the ball and the San Francisco 49ers blew ...

Two weeks after faltering on the road to the Los Angeles Rams, the 49ers blew another 10-point lead and exited with a 24-23 ...

The 49ers' biggest issue was something that's plagued them all season: They had six trips to the red zone and scored just one ...

Arizona shuts down San Francisco in second half to stage late rally after trailing by as much as 13 points on the road.

We’re now five weeks into the NFL season, and there are far more questions than answers for the San Francisco 49ers.