The 49ers' biggest issue was something that's plagued them all season: They had six trips to the red zone and scored just one ...

The 49ers just blew another 10-point fourth quarter lead and lost 24-23 to the Arizona Cardinals. Now the 49ers are 2-3. Here are their grades fo ...

Two weeks after faltering on the road to the Los Angeles Rams, the 49ers blew another 10-point lead and exited with a 24-23 ...

In anticipation of the heat, the 49ers sought a wardrobe change, but the NFL this week denied the team’s request to wear ...

The NFL denied the San Francisco 49ers' request to change to an all-white uniform set before the hottest game in Levi's ...

This marked the second time this season that San Francisco (2-3) blew a double-digit lead in the fourth quarter to a division ...

Isaac Guerendo only has six career NFL carries, but the rookie running back is making a strong impression on his 49ers ...

The 49ers traded up in the fourth round of this year's draft to land Guerendo, the former Wisconsin and Louisville running ...

The 49ers are extremely hopeful about rookie running back Isaac Guerendo. He's a bit of a project considering he never ...

The home run run plays have been missing from the 49ers’ offense so far this season. That one evaded Guerendo on Sunday, but ...

The San Francisco 49ers filled the empty spot on their practice squad on Wednesday. Defensive lineman Shakel Brown is ...

Joshua Karty hit a 37-yard field goal with two seconds remaining and the Los Angeles Rams pulled off an improbable 27-24 ...