Brock Purdy had two costly interceptions against the Cardinals, resulting in a disappointing one-point loss for the 49ers.

After Arizona's defense forced a three-and-out, the Cardinals received possession. After finding tight end Trey McBride on a ...

This was a stark contrast to the other offense in the game led by Deshaun Watson. The Commanders held Watson and the ...

Despite being largely considered the best overall quarterback in the NFL, Chiefs quarterback Patrick Mahomes is just the QB16 ...

Former Oregon Ducks and current San Francisco 49ers defensive back Deommodore Lenoir scooped the ball after a blocked field goal attempt and ran for a 60-yard t ...

San Francisco 49ers running back Jordan Mason stiff-arms Arizona Cardinals cornerback Sean Murphy-Bunting into the ground on ...

We’re now five weeks into the NFL season, and there are far more questions than answers for the San Francisco 49ers.

Tip Drill! Arizona Cardinals linebacker Mack Wilson dives for San Francisco 49ers quarterback Brock Purdy's pass for an interception.

The 49ers just blew another 10-point fourth quarter lead and lost 24-23 to the Arizona Cardinals. Now the 49ers are 2-3. Here ...

Tom Brady, FOX Sports lead NFL analyst, praised Arizona Cardinals quarterback Kyler Murray for leading a 13-point second-half ...

What's the Arizona Cardinals vs San Francisco 49ers score? Follow our live game updates for the latest news, analysis from ...

The defense wilted in the heat, the offense couldn’t finish drives or protect the ball and the San Francisco 49ers blew ...