The San Francisco 49ers were thought to be among the favorites to represent the NFC in the Super Bowl for a second straight year, but they haven't ...

After swapping his cleats for a microphone, the spotlight during Sunday's game between the San Francisco 49ers and Arizona ...

After Arizona went three-and-out, the 49ers appeared to be on their way to potentially reaching 30 points on their first drive of the second half - before a tipped pass landed in the arms of Cardinals ...

The 49ers' biggest issue was something that's plagued them all season: They had six trips to the red zone and scored just one ...

SAN FRANCISCO (AP) — When London Breed was elected as San Francisco's first Black woman mayor, it was a pinch-me moment for a poor girl from public housing whose ascension showed that no dream was ...

The 49ers just blew another 10-point fourth quarter lead and lost 24-23 to the Arizona Cardinals. Now the 49ers are 2-3. Here are their grades fo ...

Two weeks after faltering on the road to the Los Angeles Rams, the 49ers blew another 10-point lead and exited with a 24-23 ...

Kyler Murray had a long touchdown run in the first quarter and rallied Arizona with two fourth-quarter scoring drives in the ...

The record-breaking heat at Levi's Stadium on Sunday sent San Francisco 49ers fans to the concourses to watch the game on ...

San Francisco 49ers kicker Jake Moody had his ankle bent awkwardly as he trid to make a tackle on an opposing player.

The NFL denied the San Francisco 49ers' request to change to an all-white uniform set before the hottest game in Levi's ...

Anyone trekking from Sacramento to the Bay Area on Sunday to watch the San Francisco 49ers would be mistaken for thinking ...