Dual checkpoint inhibitors led to longer overall survival in patients with high-risk endometrial cancer who displayed inactivating PPP2R1A mutations vs patients with wild-type PPP2R1A.

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) functions as a key regulator in inflammation and cell death and is involved in mediating a variety of inflammatory or degenerative ...

GlobalData’s report assesses the drugs in the Serine/Threonine Protein Kinase SIK3 pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development ...

The serine/threonine protein phosphatase 5 (PP5) regulates hormone and stress-induced signaling networks. Unlike other phosphoprotein phosphatases, PP5 contains both regulatory and catalytic domains ...

CDKL5 encodes a serine-threonine kinase with significant homology to GSK3β, which has also been linked to synaptic function. Further, Cdkl5 knock-out rodents have increased GSK3β activity and often ...

Oric Pharmaceuticals Inc. has described serine/threonine-protein kinase PLK4 (STK18) inhibitors reported to be useful for the treatment of cancer.

Protein Phosphatase 2A Inhibition Can Enhance Mitochondrial Motility Cantharidin is a potent inhibitor of the serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A) and a weak inhibitor of ...

PP2A is a highly conserved serine/threonine heterotrimeric phosphatase with an essential role in many cellular processes (4). PP2A activity is inhibited in several cancers (8, 9, 11). Multiple ...

BIO, an inhibitor of GSK‐3β (glycogen synthase kinase‐3β), blocks the inhibitory effect of SGK3 (serine/threonine‐protein kinase 3) knockdown on cardiac regeneration after apical resection (AR) injury ...

In contrast to the success of prosperous kinase inhibitors, design of small molecules targeting phosphatase is struggling due to past bias and difficulty. This is especially true for serine/threonine ...