Usha Rani was married to N Shankaran Nair, who passed away in 2005. The actress has earlier been vocal about Mohanlal helping her with the academic expenses of her son, following Nair's death.

Rani emphasised the importance of mental health and therapy, particularly for the transgender community. The Times of India. Tonight, my performance is dedicated to Usha Maa: Rani KoHEnur.