Winning your fantasy football matchups in Week 3 will mean making the right choices on these tough position calls.

San Francisco 49ers quarterback Brock Purdy led the NFL in passing yards prior to Thursday Night Football with 550, but he ...

Everything you need to know about the Rams' home game against the NFC West rival San Francisco 49ers, including start time, ...

Injuries already are accruing across the league, knocking out several star players and forcing teams to turn to backups and ...

Jimmy Garoppolo knows what it feels like as a San Francisco 49er to come to L.A., but now the quarterback is on the other ...

No. 20 (2-0, 0-0 Big 12) vs Arkansas State (2-1, 0-0 Sun Belt) in Jack Trice Stadium. Kickoff is set for 1 p.m. on ESPN+.

The San Francisco 49ers and Los Angeles Rams will be missing top players because of injuries when they meet on Sunday in the ...

The San Francisco 49ers could be without another key offensive player this week after All-Pro tight end George Kittle missed practice with a sore hamstring. The Niners are lost All-Pro running back ...

The Los Angeles Rams host the San Francisco 49ers on Sunday as both NFC West rivals try to shake off dismal Week 2 ...

QB Brock Purdy addresses the media ahead of San Francisco's matchup against the Los Angeles Rams on Sunday to discuss how he'll play without his usual supporting cast because of injuries.Purdy ...

For many years, decades even, Week 1 and 2 produced misleading stats that suggested the NFL was in for a high-scoring year.

Although the famed Rams-49ers rivalry has been decidedly tilted in San Francisco’s direction in recent years, the games have ...