CD74: A marker for immunotherapy response. The team next looked for a simple way to check whether the immune system was in ...

High CD74:DDT and CD74:MIF levels were also associated with enrichment of infiltrating inflammatory cell markers. These data suggest DDT as a novel target in immune therapy.

Total RNA was extracted from tumor tissue, and the sequencing of an RT-PCR product spanning the CD74–ROS1 fusion junction revealed a c.6094G→A, p.Gly2032Arg (G2032R), mutation that had not ...

Our work suggests that testing for CD74 levels – which signal that the immune system is 'just right' to fight the tumor – could widen access to immunotherapy.

CD74's expression and function on colon intestinal epithelial cells is controversial. A research article to be published on July 14, 2010 in the World Journal of Gastroenterology addresses this ...

CD74 (P<0.001) but not MIF overexpression (P=0.231) emerged as an independent prognostic factor for prolonged OS. High expression of tumour cell calretinin correlated with the epithelioid ...

CD74 is a protein expressed by cells of the immune system. A research group in Israel finds that CD74 is expressed on colon epithelial cells of mice, as well as on a malignant cell line from mouse ...

On January 12, 2023, Oncotarget published a new research paper, entitled, “Targeting CD74 in B-cell non-Hodgkin lymphoma with the antibody-drug conjugate STRO-001.” ...

Results: In 13/14 BMB specimens, there was moderate to strong CD74 expression by leukemic blasts, which was mostly intracellular, usually with a perinuclear distribution. Three AML cell lines also ...

Notably, CD74⁺ B cells were enriched within TLS, particularly during early developmental stages. Mapped the spatially in situ developmental trajectory of CD74⁺ B cells and uncovered the dynamic ...

CD74 protein levels can predict immunotherapy response in bowel cancer, regardless of subtype. This discovery could expand treatment eligibility to patients with the proficient subtype, who ...