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Frontiers

Dissecting the immune evasion and therapeutic resistance mechanisms in EGFR/TP53 co-mutated non-small cell lung cancer: implications for targeted and immunotherapy strategies

Background: Although precision-targeted therapies and tyrosine kinase inhibitors (TKIs) have significantly improved outcomes in non-small-cell lung cancer (NSCLC), patients with EGFR-mutant NSCLC with ...
ascopubs.org

Analysis of Concordance Between Next-Generation Sequencing Assessment of Microsatellite Instability and Immunohistochemistry-Mismatch Repair From Solid Tumors

This study demonstrates that NGS-MSI is noninferior to IHC-MMR and can identify MSI-H tumors that IHC-MMR is unable to detect and conversely IHC-MMR can identify MMRd tumors that NGS-MSI misses. This ...
GitHub

mLLMCelltype: Multi-LLM Consensus Framework for Cell Type Annotation

mLLMCelltype is a multi-LLM consensus framework for automated cell type annotation in single-cell RNA sequencing (scRNA-seq) data. The framework integrates multiple large language models including ...
C&EN

Immune-Modulating Dual-Targeted Nanomaterials for Low-Temperature Photothermal–Photodynamic–Chemodynamic Therapy of Osteosarcoma Targeting Tumor and Endotheli…

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China ...