CD74 is a protein expressed by cells of the immune system. A research group in Israel finds that CD74 is expressed on colon epithelial cells of mice, as well as on a malignant cell line from mouse ...

Researchers at the Francis Crick Institute and Barts Cancer Institute, Queen Mary University of London, have shown that the amount of a protein called CD74 can indicate which people with bowel cancer ...

“Taken together, these findings provide a strong rationale for potently and selectively targeting of CD74 in patients with B-NHL [B-cell non-Hodgkin lymphoma].” BUFFALO, NY- January 17, 2023 – A new ...

Preclinical activity of the Hsp90 inhibitor, ganetespib, in ALK- and ROS1-driven cancers. BI 836845, a fully human IGF ligand neutralizing antibody, to improve the efficacy of rapamycin by blocking ...

Following antigen uptake by dendritic cells (DCs) in the periphery, the cells migrate to the lymph nodes where they can present the antigen to T cells. But how is antigen presentation coordinated with ...

A new research paper was published in Oncotarget's Volume 14 on January 12, 2023, entitled, "Targeting CD74 in B-cell non-Hodgkin lymphoma with the antibody-drug conjugate STRO-001." In this new study ...

Collaboration expanded with new cancer target Seattle Genetics has co-development option after Phase I Genmab introduces HuMax-CD74 ADC to pre-clinical pipeline COPENHAGEN, Denmark & BOTHELL, ...

Small chemotactic cytokines termed chemokines orchestrate the activation and recruitment of leukocytes during immune surveillance and inflammation. The structural classification of chemokines, their G ...

Seattle retains option to codevelop resulting candidates at end of Phase I development. Genmab has signed a second antibody-drug conjugate (ADC) research collaboration with Seattle Genetics. The new ...