The San Francisco 49ers will be without their quarterback in Week 2 vs. the New Orleans Saints, but signs on their star RB ...

How do you see this one playing out? Our staff writers made their picks for Week 2's final score and bold predictions in Saints vs. 49ers: ...

Sophia Culpo said her sister Olivia Culpo's baby, Colette, is Christian McCaffrey's "twin" in an interview with PEOPLE at the ...

The 49ers need this player to improve from his Week 1 performance when they face the Saints if they want their offense to increase in efficiency.

A rebuilding Saints pass defense is tasked with slowing down a shorthanded 49ers offense. Can New Orleans win this matchup on ...

DFS millionaire Mike McClure shares his top daily fantasy football picks and lineup advice for the Week 2 Sunday NFL schedule ...

The 2025 NFL season is finally underway, which means NFL DFS contests have arrived as well. The Sunday Week 2 NFL DFS player pool will be ...

The 49ers enter Sunday’s game in New Orleans seeking to open a season with back-to-back road wins like in 2019, ’21 and ’23.

Get the latest 49ers vs. Saints Week 2 betting preview with injury updates, data-driven predictions, projected box score ...

As a whole, it might look like a disaster in San Fran, and for their playoff prospects it likely is. However, from a fantasy ...

Head coach Kyle Shanahan addressed the status of QB Brock Purdy, T Trent Williams, and WR Jauan Jennings, highlighted the ...

Even with Brock Purdy out, Christian McCaffrey and San Francisco have what it takes to pick up a road win in New Orleans on Sunday, September 14, 2025, per our 49ers vs. Saints predictions.