Experienced fantasy football enthusiasts know that the game isn't as easy as it might seem. In theory, managers can simply draft the most productive NFL stars, set their Week 1 lineups and only make changes when injuries and bye weeks occur.

DFS millionaire Mike McClure shares his top daily fantasy football picks and lineup advice for the Week 2 Sunday NFL schedule

Carolina, just like last year, appears to be one of the league’s most prominent, easy-to-target run funnel defenses. Travis Etienne — one of the NFL’s least efficient running backs over the past two years — ran wild against the Panthers in Week 1. Only Derrick Henry averaged more yards after contact per rush in the season’s opening week.

Caleb Williams went 21-35 for 2 total TDs in the Chicago Bears’ 27-24 loss to the Minnesota Vikings. Colin Cowherd asks if this performance was encouraging or disappointing.

Now, SportsLine's NFL DFS Optimizer has turned its attention to Sunday's 2025 NFL Week 2 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.

The 49ers placed Kittle on injured reserve Tuesday, meaning he will miss at least the next four games.

The Cleveland Browns have given fantasy football players some tough decisions to make. Quinshon Judkins practiced this week for the first time since minicamp. The second-round rookie RB from Ohio State should have a role in the offense once he gets back on the field.

The Patriots passing game flashed some positive potential in Week 1 against the Raiders, but more production could come in Week 2 at Miami. I have Drake Maye listed as a starter in Start 'Em & Sit 'Em,