Tom Brady reminisced on facing San Francisco 49ers quarterback Brock Purdy in 2022, the final season of his career.

We’re now five weeks into the NFL season, and there are far more questions than answers for the San Francisco 49ers.

With the San Francisco 49ers (2-3) and the Seattle Seahawks (3-2) squaring off on Oct. 10 at Lumen Field, Brock Purdy and ...

A marathon Sunday of Week 5 produced plenty of winners and losers, with the 49ers and Bills among the teams sparking concerns ...

Half of the 10 Sunday afternoon games on the Week 5 NFL schedule are divisional matchups, but oddly, none of them features a ...

Here’s what fans and analysts were saying on Twitter after the 49ers dropped a shocking loss to the Cardinals in Week 5.

It was a good day for the future of the Las Vegas Raiders. Not because of what happened in their matchup against the Denver ...

The 49ers collect 413.3 yards per game, 58.5 more yards than the 354.8 the Cardinals allow per contest. San Francisco rushes ...

SportsLine's model simulated Arizona Cardinals vs. San Francisco 49ers 10,000 times and made its Week 5 NFL picks, ...

The Ravens (-6.5) have won three games in a row, the latest being a 41-38 thriller in overtime over Cincinnati after scoring ...

The Arizona Cardinals and San Francisco 49ers will kick off Sunday afternoon from Levi's Stadium at 1:05 p.m. Arizona time.

Want to watch the Cardinals play the 49ers? Here's everything you need to stream Sunday's 4:05 p.m. ET game on Fox.