The San Francisco 49ers will be without their quarterback in Week 2 vs. the New Orleans Saints, but signs on their star RB are good.

Learn which TV channel or how to live stream the NFL Week 2 New Orleans Saints and San Francisco 49ers game, Sunday, Sept. 14.

Who's under pressure, and who is an X-factor? Why these players could be the difference in the New Orleans Saints' outcome against the 49ers:

The 49ers enter Sunday’s game in New Orleans seeking to open a season with back-to-back road wins like in 2019, ’21 and ’23.

The New Orleans Saints may have lost against the Arizona Cardinals Week 1, but that isn't swaying Drew Brees' opnion of the team for the 2025 season in general.

The Saints won’t have defensive end Chase Young for a second consecutive game. Young injured a calf during practice in the Sept. 3 practice and has not practiced since. He played all 17 games last season. The Saints also ruled out safety Julian Blackmon (shoulder) and offensive guard Trevor Penning (toe). Neither practiced this week.

Former New Orleans Saints quarterback Derek Carr is not completely closing the door at a potential playing comeback in the NFL. Recently, Carr went on the "Dan Patrick Show," and opened up about his current mindset with the game of football.

The New Orleans Saints brought up several players from the practice squad and formalized a trade in their last-minute Week 2 roster moves: