The most significant injury for the 49ers is to their franchise quarterback, Brock Purdy. He’s expected to miss several games due to a turf toe-related ailment, forcing the team to turn to Mac Jones to run the offense for the time being. Jones was listed with a knee injury at practice this week but remained a full participant.

Brock Purdy is expected to miss the game. He’s dealing with injuries to his non-throwing shoulder and a toe. In addition, the 49ers placed tight end George Kittle on injured reserve this week because he’s dealing with a groin injury.