The most significant injury for the 49ers is to their franchise quarterback, Brock Purdy. He’s expected to miss several games ...

ORIGINAL POST: 8:00 a.m. Wednesday Vikings fans might remember Daniel Jones. He spent the tail end of last season holding a clipboard on the Minnesota sideline. And he helped the New York Giants knock ...

A rebuilding Saints pass defense is tasked with slowing down a shorthanded 49ers offense. Can New Orleans win this matchup on Sunday?

The San Francisco 49ers take on the New Orleans Saints at 10:05 a.m. PT on Sunday, Sept. 14 at the Caesars Superdome in New ...

The 49ers enter Sunday’s game in New Orleans seeking to open a season with back-to-back road wins like in 2019, ’21 and ’23.

Mac Jones finally gets the chance to start for San Francisco, four years after the 49ers considered drafting him to be their ...

Our fantasy football IR report and tracker for injured NFL players on injured reserve in Week 2 of 2025. Fantasy football ...

The San Francisco 49ers released their latest injury updates headed into the Week 2 contest versus the New Orleans Saints.

With Kittle out, the 49ers have two tight ends -- Luke Farrell and Jake Tonges -- on the roster and could use fullback Kyle ...

Even with Brock Purdy out, Christian McCaffrey and San Francisco have what it takes to pick up a road win in New Orleans on Sunday, September 14, 2025, per our 49ers vs. Saints predictions.

San Francisco 49ers offensive lineman Colton McKivitz joined "You've Got Mail" presented by Delta Dental to talk about his hometown mural, hosting a youth football camp in San Francisco, his favorite ...

The San Francisco 49ers are facing significant challenges following the announcement that star tight end George Kittle has ...