The Detroit Lions and San Francisco 49ers will square off in a rematch of last year's NFC Championship game on Monday Night Football in Week 17 at Levi's Stadium. The Lions will be looking to improve their road record to 8-0 and overall record to 14-2.

No. 2 pick Jayden Daniels and the Commanders are favored by 4.5 points in the Week 17 NFL odds, over No. 8 pick Michael Penix and the Falcons. Before that, however, a pair of veteran quarterbacks in Jordan Love and Sam Darnold will face off in Packers vs.

The San Francisco 49ers have suspended linebacker De’Vondre Campbell for three games – the rest of the regular season – after he refused to enter his team’s game in the third quarter of a 12-6 loss to the Los Angeles Rams on Thursday night.

The Detroit Lions can move one step closer to tying up top spot in the National Football Conference when they travel to the San Francisco 49ers in a

The Lions held a 17-point lead in the NFC championship game over the San Francisco 49ers before getting outscored 27-7 in the second half to lose.