Background To study the prevalence and risk factors of fragility fractures in patients with SLE.Methods 383 patients who fulfilled ≥4 ACR criteria for SLE and had a DEXA scan performed (baseline) were ...

Objective To compare (1) peripheral blood mononuclear cell (PBMC) TLR7 and TLR9 gene expression and (2) interferon stimulated gene (ISG) expression in PBMCs after stimulation with TLR7 and TLR9 ...

Objective To report the first case of a patient with refractory childhood-onset SLE successfully treated with anti-CD19 CAR-T cell therapy.

Background Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare immune-mediated neurologic disorder that targets the peripheral nerves and nerve roots which can cause progressive ...

Background Discoid lupus erythematosus (DLE) is one of the LE-specific skin diseases on the scalp, and some cases induce scarring alopecia. In systemic LE (SLE), variable nail changes not specific to ...

Background Systemic lupus erythematosus (SLE) is a female predominant autoimmune disorder. X chromosome contains the largest number of immune-related genes of entire human genome. The number of X ...

Background Chronic and latent infections like tuberculosis (TB) are known triggers for developing autoimmunity. It is not known the consequences of latent TB infection (LTBI) in individuals who are ...

Background In our studies of the relationship of the association of Epstein-Barr virus (EBV) infection with SLE we have also found an association of the anti-EBV Epstein-Barr Nuclear Antigen 1 (EBNA1) ...

Background Serious infections contribute significantly to morbidity and mortality in systemic lupus erythematosus (SLE)Methods We undertook a retrospective analysis of all SLE patients enrolled in the ...

Background Cyclophosphamide, an immunosuppressant in patients with lupus nephritis, aims to prevent recurrence and is a steroid-sparing agent. The clinical response (efficacy and toxicity) of lupus ...

Background Leukocyte immunoglobulin-like receptor A3 (LILRA3) is the soluble protein of LILRs family. LILRA3 exhibits a 6.7-kb deletion variation among individuals. The deletion removes all of four Ig ...

Background Despite the advances in the management of systemic lupus erythematosus (SLE), mortality rate among patients with SLE significantly remained higher compared to non-SLE over time. Serious ...