Because CD3 is required for T-cell activation, drugs (often monoclonal antibodies) that target it are being investigated as immunosuppressant therapies (e.g., otelixizumab, teplizumab) for …

In this review, we will focus on those strategies that directly target the CD3/TCR complex in situ—namely, CD3 specific antibodies, their variants, and CD3 aptamers (Table 1).

Aug 4, 2025 · CD3 (Cluster of Differentiation 3) is a protein complex found on the surface of T cells. It acts as a universal marker for T cells, used to identify and count T cells.

Nov 14, 2025 · The CD3 complex acts as the signal transducer, translating external recognition by the TCR into internal cellular action. The complex is composed of multiple protein chains, …

Mar 18, 2022 · CD3 is a cell surface complex composed of 4 distinct subunits; these subunits are chains of integral membrane glycoproteins that associate with T cell antigen receptor (TCR) …

CD3 is part of the T-cell receptor (TCR) complex, which is essential for T-cell activation in response to antigens. When T-cells recognize a foreign pathogen, CD3 initiates a cascade of …

The three CD3 subunits CD3γ, CD3δ, and CD3ε form an integral part of the TCR-CD3 complex and, together with CD3ζ, provide TCRαβ (and TCRγδ) with the signal transmission ability upon …

This mini-review explains the structure of CD3, the genes involved in its expression, its function and the signal transduction pathways mediated by CD3 complex.

Anti-CD3 antibodies act as potent immunosuppressive agents by modulating the CD3/T-cell receptor (TCR) complex. They have been used in patients to prevent short term allograft …

Jul 30, 2025 · CD3 is a protein complex located on the surface of T cells, serving as a defining characteristic of this cell lineage. It associates with the T cell receptor (TCR).