The pentameric structure of Stx (B5) binds to globotriaosylceramide (GB3), its receptor on the surface of the host Intestinal and kidney epithelial cells.

The A subunit of the toxin injures the eukaryotic ribosome, and halts protein synthesis in target cells. The function of the B pentamer is to bind to the cellular receptor, globotriaosylceramide, …

Globotriaosylceramide (Gb3), the receptor for Stx2, was localized to neurons of the central nervous system (CNS) of normal mice. Gb3 was not found in astrocytes or endothelial cells of …

The pathogen-derived Shiga Toxin B subunit (STxB) can be used as a carrier that detects the tumor-associated glycosphingolipid globotriaosylceramide (Gb3) receptors.

Here, we briefly summarize the Stx structure, subtypes, in vitro and in vivo models, Gb3 expression and HUS, and then introduce recent studies using CRISPR-Cas9-mediated …

Oct 1, 2024 · Binding of the B subunit of Stx to the specific receptor globotriaosylceramide (Gb3) on the cell membrane is a key step for Stx to enter cells and exert its toxicity. In this work, we …

The receptor lipid is composed of the trisaccharide α-D-galactose-(1 → 4)-β-D-galactose-(1 → 4)-β-D-glucose, bound via an acetal to a sphingosine moiety. One fatty acid is connected via an …

Here, we study the GSL globotriaosylceramide (Gb3), a key receptor involved in the cellular uptake of the Gram-negative bacterium P. aeruginosa.

Jul 26, 2021 · This review focuses on lectins binding to the glycosphingolipid globotriaosylceramide (Gb3), an attractive host cell receptor, particularly for pathogens and …

Oct 16, 2021 · Stx preferentially binds to its receptor, the glycosphingolipid, globotriaosylceramide (Gb3), present on the surface of human kidney cells and various organs. In this study, the …