Prevention of tetracycline or minocycline induced teeth staining or discoloration is most easily done by avoiding tetracycline use during periods of mineralization (or calcification), which generally occurs in children up to the age of 8 years old.

We review the literature in the area of minocycline teeth staining, consider the role of minocycline as a first-line agent for papulopustular acne, and outline strategies on the prevention of minocycline teeth staining.

Jun 7, 2020 · Minocycline and Doxycycline react with the glycoproteins of the dental pellicle, a protein film that coats the tooth enamel to help prevent the deposition of salivary calcium phosphate, which increases one’s risk of periodontitis. This interaction causes oxidation and produces stains when exposed to bacteria or sunlight.

This article presents the most common patterns of minocycline staining in addition to comparing the staining patterns of other tetracycline analogs in the permanent dentition. It also reviews the literature's most prominent theories describing the process of minocycline discoloration, and evaluates their plausibility.

Jan 13, 2025 · Antimicrobial agents such as minocycline and doxycycline are thought to bind to the glycoprotein of the pellicle, causing extrinsic staining. This occurs more frequently in individuals with poor oral hygiene.

Minocycline's contact with the teeth occurs through a few different processes, all of which are likely to contribute to the staining of the teeth. The first influence has been called the "intrinsic theory", which occurs upon absorption.

Jul 26, 2013 · Minocycline-induced staining of the sclerae, ears, gingivae and teeth is a rare but troublesome condition. This report describes one such case and highlights the dangers of long-term...

Objective: To describe a case of tooth discoloration in an adult after minocycline treatment for arthritis. Case summary: A 68-year-old white women presented with blue-black staining of her lower anterior teeth after 4 months of minocycline therapy for arthritis.

Minocycline hydrochloride, a semisynthetic derivative of tetracycline often used for the treatment of acne, has been shown to cause pigmentation of a variety of tissues including skin, thyroid, nails, sclera, teeth, conjunctiva and bone.

The undesirable effect of staining deciduous teeth has been well described and hence minocycline is not prescribed to children under the age of 8. Staining of permeant teeth is a rare occurrence.