Feb 20, 2024 · This activity provides an overview of the indications, mechanism of action, adverse effects, contraindications, and important considerations for using tirzepatide.

Tirzepatide is an analogue of gastric inhibitory polypeptide (GIP), a human hormone that stimulates the release of insulin from the pancreas. Tirzepatide is a linear polypeptide of 39 amino acids that has been chemically modified by lipidation to improve its uptake into cells and its stability to metabolism. [32] .

Mechanism of action Glucagon-like peptide-1 (GLP-1) receptors (GLP-1R) are expressed throughout the body, including pancreatic beta-cells and the gastrointestinal tract.

Aug 1, 2024 · Tirzepatide’s main mechanism of action (how it works) is mimicking two gut hormones that regulate blood glucose (sugar), digestion, and appetite. Tirzepatide helps treat Type 2 diabetes by telling the pancreas to release more insulin and the liver to make less glucose.

Tirzepatide is a peptide molecule that is produced synthetically that acts on both GIP and GLP-1 receptors as a receptor agonist. Due to this unique dual activity property, it is also referred to as ‘twincretin’.

Jul 1, 2022 · Tirzepatide is an injectable dual glucagon-like peptide 1 (GLP-1) receptor and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist (6). GIP is considered the dominant insulinotropic hormone when compared with GLP-1 and has demonstrated a stronger role in postprandial insulin secretion (7).

Dec 29, 2024 · Tirzepatide, synthetic antidiabetic drug used in the treatment of type 2 diabetes. Tirzepatide is the first drug in a class of agents known as dual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) receptor agonists.

Tirzepatide is a promising drug with dual-acting glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor activation that has revolutionized the treatment of type 2 diabetes mellitus (T2DM) as an adjunct to diet and exercise.

Sep 1, 2022 · Tirzepatide is an acylated peptide engineered to activate the GIP and GLP-1 receptors, key mediators of insulin secretion that are also expressed in regions of the brain that regulate food intake.

Sep 5, 2024 · Clinical trials examining tirzepatide's impact on glycemic and obesity control are detailed, demonstrating its efficacy in reducing body weight and appetite.